Fluorine-Modified Rutaecarpine Exerts Cyclooxygenase-2 Inhibition and Anti-inflammatory Effects in Lungs

• Main Authors: Chiming Lee (Author), Jiahnhaur Liao (Author), Seuhwa Chen (Author), Chiaohan Yen (Author), Yuchieh Lee (Author), Shihhao Huang (Author), Shengtung Huang (Author), Chunmao Lin (Author), Vincent Hungshu Chang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation is the first step that leads to inflammatory cell migration, cytokine release, and myofibroblast formation. Myofibroblasts can deposit excess amounts of extracellular matrix. Cyclooxygenase (COX) inhibitor exhibits strong anti-inflammatory response; however, this is usually achieved wit...