Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH

• Main Authors: Miren Bravo (Author), Imma Raurell (Author), Aurora Barberá (Author), Diana Hide (Author), Mar Gil (Author), Federico Estrella (Author), María Teresa Salcedo (Author), Salvador Augustin (Author), Joan Genescà (Author), María Martell (Author)
• Format: Book
• Published: The Company of Biologists, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In non-alcoholic steatohepatitis (NASH), decreased nitric oxide and increased endothelin-1 (ET-1, also known as EDN1) released by sinusoidal endothelial cells (LSEC) induce hepatic stellate cell (HSC) contraction and contribute to portal hypertension (PH). Statins improve LSEC function, and ambrisen...