Strong type 1, but impaired type 2, immune responses contribute to Orientia tsutsugamushi-induced pathology in mice.

• Main Authors: Lynn Soong (Author), Hui Wang (Author), Thomas R Shelite (Author), Yuejin Liang (Author), Nicole L Mendell (Author), Jiaren Sun (Author), Bin Gong (Author), Gustavo A Valbuena (Author), Donald H Bouyer (Author), David H Walker (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Scrub typhus is a neglected, but important, tropical disease, which puts one-third of the world's population at risk. The disease is caused by Orientia tsutsugamushi, an obligately intracellular Gram-negative bacterium. Dysregulation in immune responses is known to contribute to disease pathoge...