SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs

• Main Authors: Raed Shalaby (Author), Jacobus P. Petzer (Author), Anél Petzer (Author), Usman M. Ashraf (Author), Ealla Atari (Author), Fawaz Alasmari (Author), Sivarajan Kumarasamy (Author), Youssef Sari (Author), Ashraf Khalil (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. The IC50 values were found to be in the micromolar to submicromolar range. The...