Dimethyl Fumarate, an Approved Multiple Sclerosis Treatment, Reduces Brain Oxidative Stress in SIV-Infected Rhesus Macaques: Potential Therapeutic Repurposing for HIV Neuroprotection

• Main Authors: Yoelvis Garcia-Mesa (Author), He N. Xu (Author), Patricia Vance (Author), Analise L. Gruenewald (Author), Rolando Garza (Author), Cecily Midkiff (Author), Xavier Alvarez-Hernandez (Author), David J. Irwin (Author), Alexander J. Gill (Author), Dennis L. Kolson (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dimethyl fumarate (DMF), an antioxidant/anti-inflammatory drug approved for the treatment of multiple sclerosis, induces antioxidant enzymes, in part through transcriptional upregulation. We hypothesized that DMF administration to simian immunodeficiency virus (SIV)-infected rhesus macaques would in...