Computational analysis of fusion protein of anti-HER2 scFv and alpha luffin: A new immunotoxin protein for HER2 positive cancers

• Main Authors: Farzaneh Barkhordari (Author), Elham Rismani (Author), Maryam Tabasinezhad (Author), Saeme Asgari (Author), Leila Nematollahi (Author), Yeganeh Talebkhan (Author)
• Format: Book
• Published: Universidade de São Paulo, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The present study deals with the computational design and analysis of a novel fusion protein based on a single chain variable fragment that binds to the extracellular domain of human epidermal growth factor receptor 2 (HER2) in breast cancer cells. Alpha luffin, a small ribosome inactivatin...