Multilocus Genetic Profile Reflecting Low Dopaminergic Signaling Is Directly Associated with Obesity and Cardiometabolic Disorders Due to Antipsychotic Treatment

• Main Authors: Aurora Arrue (Author), Olga Olivas (Author), Leire Erkoreka (Author), Francisco Jose Alvarez (Author), Ainara Arnaiz (Author), Noemi Varela (Author), Ainhoa Bilbao (Author), Jose-Julio Rodríguez (Author), María Teresa Moreno-Calle (Author), Estibaliz Gordo (Author), Elena Marín (Author), Javier Garcia-Cano (Author), Estela Saez (Author), Miguel Ángel Gonzalez-Torres (Author), Mercedes Zumárraga (Author), Nieves Basterreche (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment with second-generation antipsychotics (SGAs) can cause obesity and other cardiometabolic disorders linked to D2 receptor (DRD2) and to genotypes affecting dopaminergic (DA) activity, within reward circuits. We explored the relationship of cardiometabolic alterations with single genetic pol...