Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis

• Main Authors: Soo-Hyun Kim (Author), Richard P. Redvers (Author), Lap Hing Chi (Author), Xiawei Ling (Author), Andrew J. Lucke (Author), Robert C. Reid (Author), David P. Fairlie (Author), Ana Carolina Baptista Moreno Martin (Author), Robin L. Anderson (Author), Delphine Denoyer (Author), Normand Pouliot (Author)
• Format: Book
• Published: The Company of Biologists, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Breast cancer brain metastases remain largely incurable. Although several mouse models have been developed to investigate the genes and mechanisms regulating breast cancer brain metastasis, these models often lack clinical relevance since they require the use of immunocompromised mice and/or are poo...