Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example

• Main Authors: Liliya E. Nikitina (Author), Sergei V. Kiselev (Author), Valeriya A. Startseva (Author), Andrei V. Bodrov (Author), Zulfiya R. Azizova (Author), Olga T. Shipina (Author), Inna V. Fedyunina (Author), Sergei V. Boichuk (Author), Olga A. Lodochnikova (Author), Vladimir V. Klochkov (Author), Leisan F. Galiullina (Author), Aliya V. Khaliullina (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this article we present the synthesis of enantiomerically pure sulfoxide and study the influence of this compound on hemostasis. Detailed NMR studies and molecular dynamics simulations using sodium dodecyl sulfate (SDS) membrane models indicated that the bicyclic fragment of sulfoxide was embedde...