Design, synthesis, and biological evaluation of novel androst-17β-amide structurally related compounds as dual 5α-reductase inhibitors and androgen receptor antagonists

• المؤلفون الرئيسيون: Kejing Lao (مؤلف), Guoliang Xun (مؤلف), Xingchun Gou (مؤلف), Hua Xiang (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Prostate cancer (PCa) is the second leading cause of death in men. Apart from androgen receptor, 5α-reductase has also been recognized as a potential target. In this study, a series of androst-17β-amide compounds have been designed and synthesized targeting both AR and 5α-reductase. Their anti-proli...