Assessments of CYP‑inhibition‑based drug-drug interaction between vonoprazan and poziotinib in vitro and in vivo

• Main Authors: Shan Zhou (Author), Fang-Ling Zhao (Author), Shuang-Hu Wang (Author), Yi-Ran Wang (Author), Yun Hong (Author), Quan Zhou (Author), Pei-Wu Geng (Author), Qing-Feng Luo (Author), Jian-Ping Cai (Author), Da-Peng Dai (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractContext Poziotinib and vonoprazan are two drugs mainly metabolized by CYP3A4. However, the drug-drug interaction between them is unknown.Objective To study the interaction mechanism and pharmacokinetics of poziotinib on vonoprazan.Materials and methods In vitro experiments were performed wit...