Metformin Protects against H2O2-Induced Cardiomyocyte Injury by Inhibiting the miR-1a-3p/GRP94 Pathway

• Main Authors: Ying Zhang (Author), Xue Liu (Author), Lu Zhang (Author), Xuelian Li (Author), Zhongqiu Zhou (Author), Lei Jiao (Author), Yingchun Shao (Author), Mengmeng Li (Author), Bing Leng (Author), Yuhong Zhou (Author), Tianyi Liu (Author), Qiushuang Liu (Author), Hongli Shan (Author), Zhimin Du (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ischemia-reperfusion (I/R) injury is a major side effect of the reperfusion treatment of the ischemic heart. Few therapies are available for the effective prevention of this injury caused by the oxidative stress-induced cardiomyocyte apoptosis. Metformin was shown to have a potential cardiac protect...