Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

• 主要な著者: Md. Mesbah Uddin Talukder (著者), M.F. Michelle Sim (著者), Stephen O'Rahilly (著者), J. Michael Edwardson (著者), Justin J. Rochford (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2015-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objective: Disruption of the genes encoding either seipin or 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) causes severe congenital generalized lipodystrophy (CGL) in humans. However, the function of seipin in adipogenesis remains poorly defined. We demonstrated recently that seipin can bi...