NFκB1 Dichotomously Regulates Pro-Inflammatory and Antiviral Responses in Asthma

• Main Authors: Mandy Menzel (Author), Hamid Akbarshahi (Author), Irma Mahmutovic Persson (Author), Cecilia Andersson (Author), Manoj Puthia (Author), Lena Uller (Author)
• Format: Book
• Published: Karger Publishers, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Asthma exacerbations are commonly triggered by rhinovirus infections. Viruses can activate the NFκB pathway resulting in airway inflammation and increased Th2 cytokine expression. NFκB signaling is also involved in early activation of IFNβ, which is a central mediator of antiviral responses to rhino...