No association between variation in the <it>NR4A1 </it>gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes

• Main Authors: Fritsche Andreas (Author), Stefan Norbert (Author), Claussen Claus D (Author), Schick Fritz (Author), Machann Jürgen (Author), Machicao Fausto (Author), Müssig Karsten (Author), Häring Hans-Ulrich (Author), Staiger Harald (Author)
• Format: Book
• Published: BMC, 2010-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The nuclear receptor NR4A1 is implicated in metabolic regulation in insulin-sensitive tissues, such as liver, adipose tissue, and skeletal muscle. Functional loss of NR4A1 results in insulin resistance and enhanced intramuscular and...