Critical Analysis and Optimization of Stoichiometric Ratio of Drug-Coformer on Cocrystal Design: Molecular Docking, In Vitro and In Vivo Assessment

• Main Authors: Manami Dhibar (Author), Santanu Chakraborty (Author), Souvik Basak (Author), Paramita Pattanayak (Author), Tanmay Chatterjee (Author), Balaram Ghosh (Author), Mohamed Raafat (Author), Mohammed A. S. Abourehab (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this present research, an attempt has been made to address the influence of drug-coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility and dissolution, as well as bioavailability of poorly soluble telmisartan. The chemistry behind cocrystallization and the...