BRCA1 and Its Vulnerable C-Terminal BRCT Domain: Structure, Function, Genetic Mutations and Links to Diagnosis and Treatment of Breast and Ovarian Cancer

• Main Authors: Tala Ismail (Author), Safa Alzneika (Author), Emna Riguene (Author), Salwa Al-maraghi (Author), Aya Alabdulrazzak (Author), Noof Al-Khal (Author), Sara Fetais (Author), Angelos Thanassoulas (Author), Halema AlFarsi (Author), Michail Nomikos (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The <i>BRCA1</i> is a tumor suppressor gene that encodes for the BRCA1 protein, which plays a vital role in DNA repair, cell cycle regulation, and the maintenance of genomic stability. The BRCA1 protein interacts with a variety of other proteins that play essential roles in gene regulati...