Targeting Thymidylate Synthase and tRNA-Derived Non-Coding RNAs Improves Therapeutic Sensitivity in Colorectal Cancer

• Main Authors: Changwon Yang (Author), Jisoo Song (Author), Sunwoo Park (Author), Jiyeon Ham (Author), Wonhyoung Park (Author), Hahyun Park (Author), Garam An (Author), Taeyeon Hong (Author), Hee Seung Kim (Author), Gwonhwa Song (Author), Whasun Lim (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Some colorectal cancer (CRC) patients are resistant to 5-fluorouracil (5-FU), and high expression levels of thymidylate synthase (TS) contribute to this resistance. This study investigated whether quercetin, a representative polyphenol compound, could enhance the effect of 5-FU in CRC cells. Quercet...