Phosphorylation of the Human DNA Glycosylase NEIL2 Is Affected by Oxidative Stress and Modulates Its Activity

• Main Authors: Camilla Myrup Holst (Author), Nanna Brøndum Andersen (Author), Vibeke Thinggaard (Author), Mine Tilken (Author), Sofie Lautrup (Author), Cinzia Tesauro (Author), Tinna Stevnsner (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2023-02-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

The DNA glycosylase NEIL2 plays a central role in maintaining genome integrity, in particular during oxidative stress, by recognizing oxidized base lesions and initiating repair of these via the base excision repair (BER) pathway. Post-translational modifications are important molecular switches tha...