Pharmacokinetics of Sublingual Buprenorphine Tablets Following Single and Multiple Doses in Chinese Participants With and Without Opioid Use Disorder

• Main Authors: Ruihua Dong (Author), Hongyun Wang (Author), Dandan Li (Author), Liwei Lang (Author), Frank Gray (Author), Yongzhen Liu (Author), Celine M. Laffont (Author), Malcolm Young (Author), Ji Jiang (Author), Zeyuan Liu (Author), Susan M. Learned (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Two phase I studies assessed the pharmacokinetics of buprenorphine, its metabolite norbuprenorphine, and naloxone following administration of buprenorphine/naloxone sublingual tablets in Chinese participants. Methods In the first phase I, open-label, single ascending-dose (SAD) s...