Ceftazidime-Avibactam as Osteomyelitis Therapy: A Miniseries and Review of the Literature
Bone and joint infections (BJIs) caused by multidrug-resistant gram-negative bacteria are becoming a concern due to limited therapeutic options. Although not approved for these indications, an ever-growing amount of evidence supports the efficacy and safety of ceftazidime-avibactam as a therapy for...
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| Main Authors: | , , , , , |
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| Format: | Book |
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MDPI AG,
2023-08-01T00:00:00Z.
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| Summary: | Bone and joint infections (BJIs) caused by multidrug-resistant gram-negative bacteria are becoming a concern due to limited therapeutic options. Although not approved for these indications, an ever-growing amount of evidence supports the efficacy and safety of ceftazidime-avibactam as a therapy for osteomyelitis and prosthetic joint infections. Here, we present three cases of difficult-to-treat resistant <i>Pseudomonas aeruginosa</i> osteomyelitis that were successfully treated with ceftazidime-avibactam alone or in combination therapy with fosfomycin and amikacin. Ceftazidime-avibactam was prescribed at a daily dose of 2.5 g every 8 h for 42 days in all cases. One potential drug-related adverse effect was observed, i.e., <i>Clostridioides difficile</i> infection, which occurred after fourteen days of treatment with ceftazidime-avibactam. |
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| Item Description: | 10.3390/antibiotics12081328 2079-6382 |