Drug-Drug Interactions Involving Intestinal and Hepatic CYP1A Enzymes

• Главные авторы: Florian Klomp (Автор), Christoph Wenzel (Автор), Marek Drozdzik (Автор), Stefan Oswald (Автор)
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• Опубликовано: MDPI AG, 2020-12-01T00:00:00Z.
• Предметы: article
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Cytochrome P450 (CYP) 1A enzymes are considerably expressed in the human intestine and liver and involved in the biotransformation of about 10% of marketed drugs. Despite this doubtless clinical relevance, CYP1A1 and CYP1A2 are still somewhat underestimated in terms of unwanted side effects and drug...