BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity

• Main Authors: Xiao-Jun Yu (Author), Ying-Guang Wang (Author), Rui Lu (Author), Xin-Zhen Guo (Author), Yun-Kun Qu (Author), Shan-Xi Wang (Author), Hao-Ran Xu (Author), Hao Kang (Author), Hong-Bo You (Author), Yong Xu (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Accumulating evidence indicates that intervertebral disc degeneration (IDD) is associated with diabetes mellitus (DM), while the underlying mechanisms still remain elusive. Herein, the current study sought to explore the potential molecular mechanism of IDD in diabetic rats based...