Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity

• Main Authors: Haytham O. Tawfik (Author), Moataz A. Shaldam (Author), Alessio Nocentini (Author), Rofaida Salem (Author), Hadia Almahli (Author), Sara T. Al-Rashood (Author), Claudiu T. Supuran (Author), Wagdy M. Eldehna (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carbonic anhydrases (CAs) are one of the promising targets for the development of anticancer agents. CA isoforms are implicated in various physiological processes and are expressed in both normal and cancerous cells. Thus, non-isoform selective inhibitors are associated with several side effects. Co...