Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity

• Автори: Haytham O. Tawfik (Автор), Moataz A. Shaldam (Автор), Alessio Nocentini (Автор), Rofaida Salem (Автор), Hadia Almahli (Автор), Sara T. Al-Rashood (Автор), Claudiu T. Supuran (Автор), Wagdy M. Eldehna (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Carbonic anhydrases (CAs) are one of the promising targets for the development of anticancer agents. CA isoforms are implicated in various physiological processes and are expressed in both normal and cancerous cells. Thus, non-isoform selective inhibitors are associated with several side effects. Co...