NOTCH Signaling Is Activated through Mechanical Strain in Human Bone Marrow-Derived Mesenchymal Stromal Cells

• Main Authors: Fani Ziouti (Author), Regina Ebert (Author), Maximilian Rummler (Author), Melanie Krug (Author), Sigrid Müller-Deubert (Author), Martin Lüdemann (Author), Franz Jakob (Author), Bettina M. Willie (Author), Franziska Jundt (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Skeletal development and remodeling of adult bone are critically controlled by activated NOTCH signaling in genetically modified mice. It is yet unclear whether NOTCH signaling is activated by mechanical strain sensed by bone cells. We found that expression of specific NOTCH target genes is induced...