In vitro synergistic activity of cisplatin and EGFR-targeted nanomedicine of anti-Bcl-xL siRNA in a non-small lung cancer cell line model

• Main Authors: Phuoc Vinh Nguyen (Author), Katel Hervé-Aubert (Author), Laurie Lajoie (Author), Yoann Misericordia (Author), Igor Chourpa (Author), Stéphanie David (Author), Emilie Allard-Vannier (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Apoptosis is an important process that directly affects the response of cancer cells to anticancer drugs. Among different factors involved in this process, the BcL-xL protein plays a critical role in inhibiting apoptosis induced by chemotherapy agents. Henceforth, its downregulation may have a syner...