Inhibition of Toxoplasma gondii by 1,2,4-triazole-based compounds: marked improvement in selectivity relative to the standard therapy pyrimethamine and sulfadiazine

• Κύριοι συγγραφείς: Lidia Węglińska (Συγγραφέας), Adrian Bekier (Συγγραφέας), Nazar Trotsko (Συγγραφέας), Barbara Kaproń (Συγγραφέας), Tomasz Plech (Συγγραφέας), Katarzyna Dzitko (Συγγραφέας), Agata Paneth (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

A safer treatment for toxoplasmosis would be achieved by improving the selectivity profile of novel chemotherapeutics compared to the standard therapy pyrimethamine (PYR) and sulfadiazine (SDZ). We previously reported on the identification of the compounds with imidazole-thiosemicarbazide scaffold a...