Apoptotic activity of substituted 3-O-acetyl-betulinic acid benzylamides

Acetylated betulinic acid (BA) was converted into mono-substituted benzylamides 2-14. Screening in SRB assays showed them as cytotoxic for a variety of different human tumor cell lines. While parent BA was not cytotoxic within the limits of the assay (cut-off 30 ​μM), the target amides were cytotoxi...

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Main Authors: Marie Kozubek (Author), Linda Höhlich (Author), Sophie Hoenke (Author), Hans-Peter Deigner (Author), Ahmed Al-Harrasi (Author), René Csuk (Author)
Format: Book
Published: Elsevier, 2021-12-01T00:00:00Z.
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