Paclitaxel-Induced Endothelial Dysfunction in Living Rats Is Prevented by Nicorandil via Reduction of Oxidative Stress

• Main Authors: Ken-ichi Serizawa (Author), Kenji Yogo (Author), Ken Aizawa (Author), Yoshihito Tashiro (Author), Yoko Takahari (Author), Kaori Sekine (Author), Toshihiko Suzuki (Author), Nobuhiko Ishizuka (Author), Hideyuki Ishida (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paclitaxel-eluting stents dramatically reduce rates of in-stent restenosis; however, paclitaxel is known to lead to endothelial dysfunction. Protective effects of nicorandil on paclitaxel-induced endothelial dysfunction by examining flow-mediated dilation (FMD) were investigated in anesthetized rats...