Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery

• Główni autorzy: Yue Wang (Autor), Ziwen Cai (Autor), Gaofeng Zhan (Autor), Xing Li (Autor), Shan Li (Autor), Xuan Wang (Autor), Shiyong Li (Autor), Ailin Luo (Autor)
• Format: Książka
• Wydane: MDPI AG, 2023-03-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Postoperative cognitive dysfunction (POCD) is a severe neurological complication after anesthesia and surgery. However, there is still a lack of effective clinical pharmacotherapy due to its unclear pathogenesis. Caffeic acid phenethyl ester (CAPE), which is obtained from honeybee propolis and medic...