Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1

• Автори: Mohamad-Reza Aghanoori (Автор), Vicky Margulets (Автор), Darrell R. Smith (Автор), Lorrie A. Kirshenbaum (Автор), Daniel Gitler (Автор), Paul Fernyhough (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2021-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Objective: The distal dying-back of the longest nerve fibres is a hallmark of diabetic neuropathy, and impaired provision of energy in the form of adenosine triphosphate (ATP) may contribute to this neurodegenerative process. We hypothesised that energy supplementation via glycolysis and/or mitochon...