Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1

• Main Authors: Mohamad-Reza Aghanoori (Author), Vicky Margulets (Author), Darrell R. Smith (Author), Lorrie A. Kirshenbaum (Author), Daniel Gitler (Author), Paul Fernyhough (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The distal dying-back of the longest nerve fibres is a hallmark of diabetic neuropathy, and impaired provision of energy in the form of adenosine triphosphate (ATP) may contribute to this neurodegenerative process. We hypothesised that energy supplementation via glycolysis and/or mitochon...