Endothelin Type B Receptor-Induced Sustained Ca2+ Influx Involves Gq/11/Phospholipase C-Independent, p38 Mitogen-Activated Protein Kinase-Dependent Activation of Na+/H+ Exchanger

• Main Authors: Tsunaki Higa (Author), Takahiro Horinouchi (Author), Hiroyuki Aoyagi (Author), Hiroshi Asano (Author), Tadashi Nishiya (Author), Arata Nishimoto (Author), Ikunobu Muramatsu (Author), Soichi Miwa (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mechanism for sustained Ca2+ influx activated by G protein-coupled receptors was examined. In Chinese hamster ovary cells expressing recombinant human endothelin type B receptor (ETBR) and endogenous P2Y receptor (P2Y-R), endothelin-1 elicited a sustained Ca2+ influx depending on Gq/11 protein,...