Endothelin Type B Receptor-Induced Sustained Ca2+ Influx Involves Gq/11/Phospholipase C-Independent, p38 Mitogen-Activated Protein Kinase-Dependent Activation of Na+/H+ Exchanger

• Hauptverfasser: Tsunaki Higa (Verfasst von), Takahiro Horinouchi (Verfasst von), Hiroyuki Aoyagi (Verfasst von), Hiroshi Asano (Verfasst von), Tadashi Nishiya (Verfasst von), Arata Nishimoto (Verfasst von), Ikunobu Muramatsu (Verfasst von), Soichi Miwa (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2010-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

The mechanism for sustained Ca2+ influx activated by G protein-coupled receptors was examined. In Chinese hamster ovary cells expressing recombinant human endothelin type B receptor (ETBR) and endogenous P2Y receptor (P2Y-R), endothelin-1 elicited a sustained Ca2+ influx depending on Gq/11 protein,...