Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase.

Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a chemically and genetically validated target in African trypanosomes, causative agents of sleeping sickness in humans and nagana in cattle. Here we report the kinetic properties and sensitivity of recombinant enzyme to a range o...

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Main Authors: Marc W Gibson (Author), Simon Dewar (Author), Han B Ong (Author), Natasha Sienkiewicz (Author), Alan H Fairlamb (Author)
Format: Book
Published: Public Library of Science (PLoS), 2016-05-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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