Association of Variability and Pharmacogenomics With Bioequivalence of Gefitinib in Healthy Male Subjects

• Main Authors: Hong Zhang (Author), Qingmei Li (Author), Xiaoxue Zhu (Author), Min Wu (Author), Cuiyun Li (Author), Xiaojiao Li (Author), Chengjiao Liu (Author), Zhenwei Shen (Author), Yanhua Ding (Author), Shucheng Hua (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The aim of the study was to explore the association of pharmacokinetic variability and pharmacogenomics with the bioequivalence of orally administered gefitinib (Iressa®, AstraZeneca) provided by three sponsors in healthy subjects.Methods: The study designs were randomized, open-label, an...