Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis.

• Main Authors: Oluwatoyin A Asojo (Author), Alan Kelleher (Author), Zhuyun Liu (Author), Jeroen Pollet (Author), Elissa M Hudspeth (Author), Wanderson C Rezende (Author), Mallory Jo Groen (Author), Christopher A Seid (Author), Maha Abdeladhim (Author), Shannon Townsend (Author), Waldione de Castro (Author), Antonio Mendes-Sousa (Author), Daniella Castanheira Bartholomeu (Author), Ricardo Toshio Fujiwara (Author), Maria Elena Bottazzi (Author), Peter J Hotez (Author), Bin Zhan (Author), Fabiano Oliveira (Author), Shaden Kamhawi (Author), Jesus G Valenzuela (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Immunity to the sand fly salivary protein SALO (Salivary Anticomplement of Lutzomyia longipalpis) protected hamsters against Leishmania infantum and L. braziliensis infection and, more recently, a vaccine combination of a genetically modified Leishmania with SALO conferred strong protecti...