Population pharmacokinetics and model-based dosing evaluation of bedaquiline in multidrug-resistant tuberculosis patients

• Main Authors: Ge Shao (Author), Ziwei Bao (Author), Lina Davies Forsman (Author), Jakob Paues (Author), Jim Werngren (Author), Katarina Niward (Author), Thomas Schön (Author), Judith Bruchfeld (Author), Jan-Willem Alffenaar (Author), Yi Hu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: Bedaquiline is now recommended to all patients in the treatment of multidrug-resistant tuberculosis (MDR-TB) using standard dosing regimens. As the ability to measure blood drug concentrations is very limited, little is known about drug exposure and treatment outcome. Thus, this study aimed to...