Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety

• Main Authors: Okka Scholz (Author), Elena Huß (Author), Silke Otter (Author), Diran Herebian (Author), Anna Hamacher (Author), Laura Mariana Levy (Author), Stanimira Hristeva (Author), Miguel Sanz (Author), Haresh Ajani (Author), Alfredo Rodriguez Puentes (Author), Torsten Hoffmann (Author), Jens Hogeback (Author), Anke Unger (Author), Susanne Terheyden (Author), Michelle Reina do Fundo (Author), Bedair Dewidar (Author), Michael Roden (Author), Eckhard Lammert (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Dextromethorphan (DXM) is a commonly used antitussive medication with positive effects in people with type 2 diabetes mellitus, since it increases glucose tolerance and protects pancreatic islets from cell death. However, its use as an antidiabetic medication is limited due to its central...