Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes

• Prif Awduron: Andrea Castro (Awdur), Kivilcim Ozturk (Awdur), Rachel Marty Pyke (Awdur), Su Xian (Awdur), Maurizio Zanetti (Awdur), Hannah Carter (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: BMC, 2019-07-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Abstract Background The major histocompatibility complex class I (MHC-I) molecule is a protein complex that displays intracellular peptides to T cells, allowing the immune system to recognize and destroy infected or cancerous cells. MHC-I is composed of a highly polymorphic HLA-encoded alpha chain t...