Design, synthesis, characterization and antidiabetic evaluation of 3,5-substituted thiazolidinediones: Evidenced by network pharmacology, Molecular docking, dynamic simulation, in vitro and in vivo assessment

• Autors principals: Shankar Gharge (Autor), Shankar G. Alegaon (Autor), Swaroop Jadhav (Autor), Shriram D. Ranade (Autor), Rohini S. Kavalapure (Autor)
• Format: Llibre
• Publicat: Elsevier, 2024-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

In search of new antidiabetic agents, heterocyclic compounds containing 3,5-Substituted thiazolidinedione moieties were synthesized through a concise three-step reaction process. The synthesis involved Knoevenagel condensation at the 5th position of the 3,5-Substituted thiazolidinedione ring-system...