Effects of the Fluoroquinolone Antibacterial Drug Ciprofloxacin on Ventricular Repolarization in the Halothane-Anesthetized Guinea Pig

• Main Authors: Kazuhiro Matsuo (Author), Kaori Fujiwara (Author), Naoki Omuro (Author), Itsuki Kimura (Author), Kazuko Kobayashi (Author), Takashi Yoshio (Author), Akira Takahara (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The fluoroquinolone antibiotic ciprofloxacin has been reported to block delayed rectifier K+ channels at much higher concentrations than those at which it exerts its bactericidal activity. In this study using the halothane-anesthetized guinea pig, we assessed whether ciprofloxacin has a proarrhythmi...