IFN-α/β Signaling Is Required for CDG-Mediated CTL Generation and B Lymphocyte Activation

• Main Authors: Ahmed E. I. Hamouda (Author), Kai Schulze (Author), Thomas Ebensen (Author), Carlos Alberto Guzmán (Author), Darío Lirussi (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Among cyclic di-nucleotides (CDN), both cyclic di-AMP (CDA) and di-GMP (CDG) are promising adjuvants and immune modulators. These molecules are not only able to induce profuse antibody production but also predominant T helper 1 and cytotoxic CD8 T lymphocytes (CTL) responses, which enable their use...