Efficient Peroral Delivery of Insulin via Vitamin B12 Modified Trimethyl Chitosan Nanoparticles

• Main Authors: Zhiyang Ke (Author), Han Guo (Author), Xi Zhu (Author), Yun Jin (Author), Yuan Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE: We investigated the effect of vitamin B12 (VB12) modification on the insulin absorption from trimethyl chitosan(TMC) nanoparticles (NPs) under the influence of mucus. METHODS: TMC and TMC-VB12 were synthesized and insulin loaded TMC/TMC-VB12 nanoparticles were prepared and characterized. Mod...