Renal and vascular effects of kallikrein inhibition in a model of Lonomia obliqua venom-induced acute kidney injury.

• Main Authors: Markus Berger (Author), João Alfredo de Moraes (Author), Walter Orlando Beys- (Author), Lucélia Santi (Author), Paula Barros Terraciano (Author), David Driemeier (Author), Elizabeth Obino Cirne-Lima (Author), Eduardo Pandolfi Passos (Author), Maria Aparecida Ribeiro Vieira (Author), Thereza Christina Barja-Fidalgo (Author), Jorge Almeida Guimarães (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Lonomia obliqua venom is nephrotoxic and acute kidney injury (AKI) is the main cause of death among envenomed victims. Mechanism underlying L. obliqua-induced AKI involves renal hypoperfusion, inflammation, tubular necrosis and loss of glomerular filtration and tubular reabsorption capaci...