DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis

• Main Authors: Mingquan Sha (Author), Genxiang Mao (Author), Guofu Wang (Author), Yufeng Chen (Author), Xiaojian Wu (Author), Zhen Wang (Author)
• Formato: Libro
• Publicado: Elsevier, 2015-05-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

EZH2 is over-expressed in human colon cancer and is closely associated with tumor proliferation, metastasis and poor prognosis. Targeting and inhibiting EZH2 may be an effective therapeutic strategy for colon cancer. 3-Deazaneplanocin A (DZNep), as an EZH2 inhibitor, can suppress cancer cell growth....