Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish

• Автори: Seok-Hyung Kim (Автор), Marie L. Kowalski (Автор), Robert P. Carson (Автор), L. Richard Bridges (Автор), Kevin C. Ess (Автор)
• Формат: Книга
• Опубліковано: The Company of Biologists, 2013-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

SUMMARY Tuberous sclerosis complex (TSC) is a multi-organ disorder caused by mutations of the TSC1 or TSC2 genes. A key function of these genes is to inhibit mTORC1 (mechanistic target of rapamycin complex 1) kinase signaling. Cells deficient for TSC1 or TSC2 have increased mTORC1 signaling and give...