Design and Mechanism of Action of a New Prototype of Combi-Molecule "Programed" to Release Bioactive Species at a pH Range Akin to That of the Tumor Microenvironment

Design and Mechanism of Action of a New Prototype of Combi-Molecule "Programed" to Release Bioactive Species at a pH Range Akin to That of the Tumor Microenvironment

The clinical use of cytotoxic agents is plagued by systemic toxicity. We report a novel approach that seeks to design a "combi-molecule" to behave as an alkylating agent on its own and to undergo acid-catalyzed conversion to two bioactive species at a pH range akin to that of a tumor micro...

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Bibliographic Details
Main Authors: Anne-Laure La (Author), Etienne Chatelut (Author), Jean-Pierre Delord (Author), Diane-Charlotte Imbs (Author), Philippe Rochaix (Author), Bertrand Jean-Claude (Author), Ben Allal (Author)
Format: Book
Published: MDPI AG, 2021-02-01T00:00:00Z.
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3rd Floor Main Library

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