Design and Mechanism of Action of a New Prototype of Combi-Molecule "Programed" to Release Bioactive Species at a pH Range Akin to That of the Tumor Microenvironment

• Autores principales: Anne-Laure La (Autor), Etienne Chatelut (Autor), Jean-Pierre Delord (Autor), Diane-Charlotte Imbs (Autor), Philippe Rochaix (Autor), Bertrand Jean-Claude (Autor), Ben Allal (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2021-02-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The clinical use of cytotoxic agents is plagued by systemic toxicity. We report a novel approach that seeks to design a "combi-molecule" to behave as an alkylating agent on its own and to undergo acid-catalyzed conversion to two bioactive species at a pH range akin to that of a tumor micro...