Cancer-derived exosome miRNAs induce skeletal muscle wasting by Bcl-2-mediated apoptosis in colon cancer cachexia

• Main Authors: Chunxiao Miao (Author), Wanli Zhang (Author), Lixing Feng (Author), Xiaofan Gu (Author), Qiang Shen (Author), Shanshan Lu (Author), Meng Fan (Author), Yiwei Li (Author), Xianling Guo (Author), Yushui Ma (Author), Xuan Liu (Author), Hui Wang (Author), Xiongwen Zhang (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer cachexia is a kind of whole-body metabolic disorder syndrome accompanied by severe wasting of muscle tissue in which cancer exosomes may be involved. Analysis of clinical samples showed that the serum exosome concentrations were correlated with the development of cancer cachexia. Exosomes sec...