Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights

• मुख्य लेखकों: Waleed A. Badawi (लेखक), Mahmoud Rashed (लेखक), Alessio Nocentini (लेखक), Alessandro Bonardi (लेखक), Mohammad M. Abd-Alhaseeb (लेखक), Sara T. Al-Rashood (लेखक), Giri Babu Veerakanellore (लेखक), Taghreed A. Majrashi (लेखक), Eslam B. Elkaeed (लेखक), Bahaa Elgendy (लेखक), Paola Gratteri (लेखक), Claudiu T. Supuran (लेखक), Wagdy M. Eldehna (लेखक), Mohamed Elagawany (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Multiple inhibitions of CA, COX-2 and 5-LOX enzymes has been recognised as a useful strategy for the development of anti-inflammatory drugs that can avoid the disadvantages of using NSAIDs alone. Here, we report new pyridazine-based sulphonamides (5a-c and 7a-f) as potential multi-target anti-inflam...