Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights

• Main Authors: Waleed A. Badawi (Author), Mahmoud Rashed (Author), Alessio Nocentini (Author), Alessandro Bonardi (Author), Mohammad M. Abd-Alhaseeb (Author), Sara T. Al-Rashood (Author), Giri Babu Veerakanellore (Author), Taghreed A. Majrashi (Author), Eslam B. Elkaeed (Author), Bahaa Elgendy (Author), Paola Gratteri (Author), Claudiu T. Supuran (Author), Wagdy M. Eldehna (Author), Mohamed Elagawany (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multiple inhibitions of CA, COX-2 and 5-LOX enzymes has been recognised as a useful strategy for the development of anti-inflammatory drugs that can avoid the disadvantages of using NSAIDs alone. Here, we report new pyridazine-based sulphonamides (5a-c and 7a-f) as potential multi-target anti-inflam...