Double-layered osmotic pump controlled release tablets of actarit: In vitro and in vivo evaluation

• Autores principales: Yuenan Li (Autor), Hao Pan (Autor), Hongliang Duan (Autor), Jianting Chen (Autor), Zhihong Zhu (Autor), Jingxin Fan (Autor), Pingfei Li (Autor), Xinggang Yang (Autor), Weisan Pan (Autor)
• Formato: Libro
• Publicado: Elsevier, 2019-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The aim of the study was to develop actarit double-layered osmotic pump tablets to overcome the weak points of actarit common tablets, such as short half-life and large plasma concentration fluctuations. Single factor experiment and orthogonal test were applied to optimize the formulation; the pharm...