Double-layered osmotic pump controlled release tablets of actarit: In vitro and in vivo evaluation

• Main Authors: Yuenan Li (Author), Hao Pan (Author), Hongliang Duan (Author), Jianting Chen (Author), Zhihong Zhu (Author), Jingxin Fan (Author), Pingfei Li (Author), Xinggang Yang (Author), Weisan Pan (Author)
• Format: Book
• Published: Elsevier, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the study was to develop actarit double-layered osmotic pump tablets to overcome the weak points of actarit common tablets, such as short half-life and large plasma concentration fluctuations. Single factor experiment and orthogonal test were applied to optimize the formulation; the pharm...