Ribose 5-phosphate isomerase B knockdown compromises Trypanosoma brucei bloodstream form infectivity.

• Main Authors: Inês Loureiro (Author), Joana Faria (Author), Christine Clayton (Author), Sandra Macedo-Ribeiro (Author), Nuno Santarém (Author), Nilanjan Roy (Author), Anabela Cordeiro- (Author), Joana Tavares (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ribose 5-phosphate isomerase is an enzyme involved in the non-oxidative branch of the pentose phosphate pathway, and catalyzes the inter-conversion of D-ribose 5-phosphate and D-ribulose 5-phosphate. Trypanosomatids, including the agent of African sleeping sickness namely Trypanosoma brucei, have a...